EDITORIAL
| Where Are You Now? Trevor Laird 651-651 |
| Full: PDF (14 K) |
HIGHLIGHTS FROM THE LITERATURE
| Some Items of Interest to Process R&D Chemists and Engineers Mark McLaughlin, Silvina García Rubio, Ulf Tilstam, Octavio Augusto Ceva Antunes, Trevor Laird, and Andrei Zlota 652-662 |
| Full: PDF (271 K) |
HIGHLIGHTS FROM THE PATENTS
| A Review of U.S. Patents in the Field of Organic Process Development Published Between January and March 2007 Keith Turner 663-673 |
| Full: PDF (237 K) |
FULL PAPERS
| Development of a Practical and Reliable Synthesis of Laquinimod Johan Wennerberg, Anders Björk, Tomas Fristedt, Bo Granquist, Karl Jansson, and Ingela Thuvesson 674-680  |
| Full: PDF (83 K) |
| Hydrogenation of Nitrobenzene to 4-Aminophenol over Supported Platinum Catalysts Setrak K. Tanielyan, Jayesh J. Nair, Norman Marin, Gabriela Alvez, Robert J. McNair, Dingjun Wang, and Robert L. Augustine 681-688  |
| Full: PDF (287 K) |
| A Short and Efficient Synthesis of (R,R)-2-Methylcyclopropanecarboxylic Acid Laurent Delhaye, Alain Merschaert, Pieter Delbeke, and Willy Briône 689-692  |
| Full: PDF (130 K) |
| Process Development for ABT-472, a Benzimidazole PARP Inhibitor Jufang H. Barkalow, Jeffrey Breting, Bruce J. Gaede, Anthony R. Haight, Rodger Henry, Brian Kotecki, Jianzhang Mei, Kurt B. Pearl, Jason S. Tedrow, and Shekhar K. Viswanath 693-698  |
| Full: PDF (112 K) |
| Generation of Fine Pharmaceutical Particles via Controlled Secondary Nucleation under High Shear Environment during Crystallization - Process Development and Scale-up T. Kamahara, M. Takasuga, H. H. Tung, K. Hanaki, T. Fukunaka, B. Izzo, J. Nakada, Y. Yabuki, and Y. Kato 699-703  |
| Full: PDF (261 K) |
| Mesoscale Flow Chemistry: A Plug-Flow Approach to Reaction Optimisation Rob C. Wheeler, Otman Benali, Martyn Deal, Elizabeth Farrant, Simon J. F. MacDonald, and Brian H. Warrington 704-710  |
| Full: PDF (626 K) |
| A Facile Preparation of an Octahydropyrrolo[2,3-c]pyridine Enantiomer Wen-Chung Shieh, Guang-Pei Chen, Song Xue, Joseph McKenna, Xinglong Jiang, Kapa Prasad, Oljan Repic, Christopher Straub, and Sushil K. Sharma 711-715  |
| Full: PDF (93 K) |
| Development of a Scaleable Synthesis of NDT 9533750, a Key Intermediate to a Series of Novel Subtype Preferring GABAA Partial Agonists Yuelian Xu, Bingsong Han, Zhe-Qing Wang, Kenneth R. Shaw, Bertrand L. Chenard, George Maynard, and Linghong Xie 716-720  |
| Full: PDF (109 K) |
| Optimization and Scale-Up of the Grandberg Synthesis of 2-Methyltryptamine Joel Slade, David Parker, Michael Girgis, Raeann Wu, Scott Joseph, and Oljan Repic 721-725  |
| Full: PDF (91 K) |
| Development of a Large-Scale Stereoselective Process for (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride Zhengxu Han, Stefan G. Koenig, Hang Zhao, Xiping Su, Surendra P. Singh, and Roger P. Bakale 726-730  |
| Full: PDF (80 K) |
| Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2. Process Improvement for Scale-Up Of 2,5,8-Substituted 11,12-Dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta-[1,2-a]naphthalene Derivatives Xun Li, Michael Reuman, Ronald K. Russell, Scott Youells, Sandra Beish, Zhiyong Hu, Shawn Branum, Nareshkumar Jain, and Zhihua Sui 731-738  |
| Full: PDF (115 K) |
| One-Pot Process for the Amination of Oxazolidinyl-methyl Mesylate by Sodium Diformylamide Jinchu Liu, Mark Cameron, Scott Hoerrner, J. Michael Williams, and James McNamara 739-741  |
| Full: PDF (49 K) |
| Development of an Alternative Process for the Manufacture of a Key Starting Material for Cefovecin Sodium Timothy Norris, Isao Nagakura, Hiromasa Morita, Grant McLachlan, and Joe Desneves 742-746  |
| Full: PDF (84 K) |
| Development of a Scalable Process for DG-041, a Potent EP3 Receptor Antagonist, via Tandem Heck Reactions Siead Zegar, Christopher Tokar, Livia A. Enache, Venkat Rajagopol, Wayne Zeller, Matthew O'Connell, Jasbir Singh, Frank W. Muellner, and David E. Zembower 747-753  |
| Full: PDF (88 K) |
| Route Development and Bulk Synthesis of CP-865,569 Katherine Belecki, Martin Berliner, Richard Todd Bibart, Cliff Meltz, Karl Ng, James Phillips, David H. Brown Ripin, and Michael Vetelino 754-761  |
| Full: PDF (96 K) |
| Execution of a Performic Acid Oxidation on Multikilogram Scale David H. Brown Ripin, Gerald A. Weisenburger, David J. am Ende, David R. Bill, Pamela J. Clifford, Clifford N. Meltz, and James E. Phillips 762-765  |
| Full: PDF (141 K) |
| SiliaCat TEMPO: An Effective and Useful Oxidizing Catalyst Annie Michaud, Geneviève Gingras, Michel Morin, François Béland, Rosaria Ciriminna, David Avnir, and Mario Pagliaro 766-768  |
| Full: PDF (34 K) |
TECHNICAL NOTES
| Pd-Smopex-111: A New Catalyst for Heck and Suzuki Cross-Coupling Reactions Xinglong Jiang, Joseph Sclafani, Kapa Prasad, Oljan Repic, and Thomas J. Blacklock 769-772  |
| Full: PDF (73 K) |
| An Improved Procedure for Preparation of Carbapenem Antibiotic: Meropenem Neera Tewari, Hashim Nizar, Bishwa Prakash Rai, Shailendra K Singh, Vinod George, and Mohan Prasad 773-775  |
| Full: PDF (41 K) |
| Scale-Up of the Preparation of (1R,2R,4S)-1-Methyl-4-(1-methylethenyl)-2-(4-morpholinyl)cyclohexanol Christian T. Goralski, Dennis L. Hasha, Bakthan Singaram, and Derek Steiner 776-779  |
| Full: PDF (65 K) |
ADDITIONS & CORRECTIONS
| Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram: A Key Intermediate for Escitalopram Chandrashekar R. Elati, Naveenkumar Kolla, Pravinchandra J. Vankawala, Srinivas Gangula, Subrahmanyeswarara Chalamala, Venkatraman Sundaram, Apurba Bhattacharya, Himabindu Vurimidi,, and Vijayavitthal T. Mathad 780-780 |
| Full: PDF (10 K) |
BOOK REVIEWS
| Bretherick's Handbook of Reactive Chemical Hazards, 7th edition Edited by P. G. Urben. Academic Press: Oxford. 2007. 2 Volumes, Volume 1: 282 pp, Volume 2: 446 pp. £119. Set: ISBN-13 978-0-12-372563-9, ISBN-10 0-12-372563-1. Volume 1: ISBN-13 978-0-12-373945-2, ISBN-10 0-12-373945-4. Volume 2: ISBN-13 978-0-12-373946-9, ISBN-10 0-12-373946-2. W. J. Watson 781-781 |
| Full: PDF (7 K) |
| Making Crystals by Design, Methods, Techniques and Applications Edited by Dario Braga and Fabrizia Grepioni. Wiley-VCH Verlag GmbH: Weinheim. 2007. 347 + xiv pp. Euro 149. ISBN 978-3-527-31506-2. T. Laird 782-782 |
| Full: PDF (5 K) |